This WOCSDICE 2010 paper by Handel, Truong, Nasiri Avanaki, Sherif, and Morkoç examines quantum 1/f noise in FET-based biochemical sensors. The research analyzes fundamental quantum noise limitations in field-effect transistor sensors for detecting biomolecules, investigating how device geometry, surface functionalization, and operating conditions affect noise performance and detection limits, providing design guidelines for optimizing sensitivity in label-free electronic biosensors for medical diagnostics, drug discovery, and environmental monitoring applications.