This paper by Handel and Truong examines noise limitations of FET-based biochemical sensors, presented at ICNF 2009. The research analyzes how various noise sources including quantum 1/f noise, thermal noise, and flicker noise in field-effect transistor based biosensors limit detection sensitivity for biomolecules, providing theoretical framework for predicting minimum detectable concentrations and designing optimized FET sensor geometries and surface functionalization strategies for label-free electronic detection of proteins, DNA, and small molecules in medical diagnostics.